Ptolemy may refer to:
- Claudius Ptolemaeus, also known as "Ptolemy", a Human living in ancient Rome on Earth in the 2nd century.
- USS Ptolemy (Daedalus-class), a United Earth Starfleet Daedalus-class starship
- USS Ptolemy (NCC-3801), a Federation Starfleet Ptolemy-class starship
- SS Ptolemy (NCC-3801), a Federation freighter
- USS Ptolemy (NCC-150), a Federation Starfleet Daedalus-class starship
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