Sacajawea or Sacagawea could refer to:
- Sacagawea probe
- Sacajawea (Human)
- Sacajawea (NCC-74656/05), a 24th century Type-6 shuttlecraft
- USS Sacajawea (Hermes-class), a 23rd century starship
- USS Sacajawea (Niagara-class), a 24th century starship
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