Sam, or as a shortening of Samuel, may refer to:
- People
- Sam (bartender), bartender aboard the USS Enterprise-E
- Sam (cadet), a cadet
- Sam (Crewman), a technician aboard the USS Enterprise
- Sam (fish), a fish
- Sam (miner), a miner
- Sam (Vulcan)
- Sam Andrews, a security officer aboard the USS Endeavour
- Sam Bowers, officer aboard Deep Space 9 and the USS Aventine
- Sam Fuller, a security officer aboard the USS Enterprise
- Sam Gooding, a 23rd century Human reporter
- Sam Kerby, ensign and pilot aboard the USS Enterprise
- Sam Lavelle, tactical officer aboard the USS Enterprise-D and -E
- Sam Redbay, engineer assigned to the USS Enterprise-D
- Sam Spade, fictional detective
- Samuel Boma, astrophysicist aboard the USS Enterprise
- Samuel Carter, crewman aboard the USS Enterprise-D
- Samuel Chen, chairman of the physical education department at Starfleet Academy
- Samuel Clarkson, a transporter technology expert at Deep Space Research Facility 39
- Samuel Clemens, author also known as "Mark Twain"
- Samuel Cogley, 23rd century attorney
- Samuel Gardner, United Earth Starfleet officer in the 22nd century
- Samuel Kirk, grandfather of James T. Kirk
- Samuel Morse, inventor of Morse Code
- Samuel Solomon Qasr, Federation President in the 23rd century
- Samuel Tashket, a farmer on Sheridan's World
- Samuel Wellington, a farmer on Sheridan's World
- Samuel Winters, first officer of the USS Enterprise-F
- Samuel Winters (mirror), first officer of the ISS Enterprise-F
- George Samuel Kirk, Sr., father of James T. Kirk
- George Samuel Kirk, Sr. (Kelvin timeline), his Kelvin timeline counterpart
- George Samuel Kirk, Sr. (mirror), his mirror universe counterpart
- George Samuel Kirk, Jr., brother of James T. Kirk
- George Samuel Kirk, Jr. (Kelvin timeline), his Kelvin timeline counterpart
- George Samuel Kirk, Jr. (mirror), his mirror universe counterpart
- Tiberius "Samuel" Kirk, grandfather of James T. Kirk, known to him as Samuel Kirk
- Real-world topics:
- Sam (comic), a New Visions story
- Sam Johnson, a Last Unicorn RPG author
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