Sandra could refer to:
- People
- Sandra, a woman who dated Jean-Luc Picard during his Academy days
- Sandra Alderson, science officer of the USS Enterprise-B
- Sandra Beckzr, President of the planet Arris
- Sandra Borders, senior exobiology librarian at Memory Alpha
- Sandra Cohen, a general, author of Tactics in Space War
- Sandra Chao, a security officer aboard the USS Enterprise-E
- Sandra Earle, CO of the USS John Ross
- Sandra Eloth, a 23rd century Federation President
- Sandra M.J. Entwhistle, a Starfleet Intelligence flag officer stationed at Starbase 7
- Sandra Fritz, mother of Lewis Zimmerman
- Sanddra Hollander, a colonist on Sheridan's World
- Sandra Kingman, chief helmsman of the USS Niwen
- Sandra MacDugall, a colonist on Sheridan's World
- Sandra Mollo, daughter of Martin Mollo, a colonist on Sheridan's World
- Sandra Murchison, a history teacher aboard the USS Enterprise-D
- Sandra Pastur, a biologist aboard the USS Excelsior
- Sandra Peterson, a crewmember aboard USS Voyager
- Sandra Rhodes, security chief of Starbase 234
- Sandra Silverman, an enlisted crewperson assigned to Deep Space 9
- Sandra Vallis, a physician in the Mariposa colony
- Sandra Vashenka, a science officer aboard the USS Yorktown
- Sandra West, a nurse aboard the USS Enterprise
- Sandra Yuan, a security guard aboard the USS Pioneer
- Real-world topics
- Sandra Lanz, a comic book writer and artist
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