Sara or Sarah could refer to:
- People
- Sara, a 23rd century Human
- Sara George, an ensign with the Starfleet Cultural Survey Bureau
- Sara Nave, chief of security of the USS Enterprise-E
- Sara Paul, science officer of the USS Fortuna
- Sara Pran Yee, a musician in the A.C. Walden Medicine Show troupe
- Sara Tuchinsky, transporter chief of the USS Enterprise-A
- Sarah
- Sarah (aunt), a relative of Paul Stamets
- Sarah Poole-April, CMO of the USS Enterprise in the 2240s
- Sarah April (mirror), Terran Empire inventor of the agonizer
- Sarah Brennan, a 24th century Starfleet Admiral
- Sarah Garrett, sister of Starfleet Captain Rachel Garrett
- Sarah Gilman, daughter of David Gold and Rachel Gilman
- Sarah Hastings, a chairman of the UFP/Independent Traders Association
- Sarah Jane Smith, a 20th century journalist
- Sara Kester, a professor of tactical sciences at Starfleet Academy
- Sarah Kilmer, a 23rd century Human
- Sarah Lopez, an engineer aboard the USS Enterprise
- Sarah MacDougal, a chief engineer aboard the USS Enterprise-D
- Sarah Meier, governor of California in the 2270s
- Sarah Peterson, a medic aboard the USS Enterprise
- Sarah Sisko, mother of Starfleet Captain Benjamin Sisko
- Sarah Susan Eckert, a President of the United States
- Real-world topics
- Sarah A. Hoyt, a Strange New Worlds contest author
- Sara Pichelli, an IDW Publishing artist
- Sarah A. Seaborne, a Strange New Worlds contest author
- Sarah Shaw, a pseudonym of David Mack
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