The Science Institute on Mempa V (or simply the Science Institute) was an institution of research and higher learning in the Klingon Empire, located on the planet Mempa V. It was considered the most prestigious institute of its kind within the Empire.

Kurak, daughter of Haleka worked under the legendary engineer Makros at the Science Institute. (KE novel: A Burning House)

Lieutenant Vall decided against going to the Science Institute, over the objections of his family, in order to seek glory in the Klingon Defense Force. (TNG novel: Diplomatic Implausibility)

The Science Institute worked for many turns on a method to counter the Dominion tactic of using antiproton beams to detect cloaked ships. They had developed a solution by early 2381; however, during the Borg Invasion of 2381, the Institute facilities had to be abandoned, and the Institute re-established on Ty'Gokor. They were able to preserve their work files, and to replicate the new cloak in short order. (ST novel: A Singular Destiny)

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