Sebastian could refer to:
- People
- Sebastian Dagny, a Starfleet commander
- Sebastian Parvenu, administrator of Multiplanet Metals' lab at Deep Space Research Facility 39
- Sebastian Stolovitzky, brother of USS Enterprise-E security officer Natasha Stolovitzky
- Sebastian Westervliet, a.k.a. James Komack, a Starfleet admiral
- Johann Sebastian Bach, a noted 18th century Human composer
- Syreeta Sebastian, governor of the colony on Carina VII
- Fictional characters
- Sebastian, a character in William Shakespeare's play The Tempest
- Places
- St. Sebastian, a.k.a. Psi Nu Alpha, a Federation planet
- Real-world topics
- Sebastian Rapp, chief editor of the Star Trek: Catan board game
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