The Shackleton Expanse is a largely unexplored region of space in the Beta Quadrant, in and around the Narendra sector, near Federation Starbase 364 and the Romulan Star Empire. Numerous spatial anomalies and other interstellar phenomena can be found within the Expanse. Starfleet investigated the area to find a defense against the Borg. (Star Trek Adventures modules: Core Rulebook, Beta Quadrant Sourcebook)
- The Shackleton Expanse is the primary setting for "The Living Campaign" supplements for Star Trek Adventures released by Modiphius.
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