A spore was a one-celled reproductive body generated by some plants and fungi.

The spores of the plant species native to the planet K-G typically infected animal life-forms, transforming them into trees. These spores could survive in space and were so powerful that they could pass through the hull of a starship. In 2266, this happened to the guinea pigs on board the USS Enterprise, which had flown through a "space fog" containing the spores. On the planet itself, Crewman Hunt also became infected with the spores. (TOS comic: "The Planet of No Return")

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