|This article or subsection has an associated category.||DS9 season 5|
The series returned to the storyline of the Dominion threat to the Alpha Quadrant, with Jem'Hadar ships invading in "In Purgatory's Shadow". Dukat allies with the Dominion and Cardassian space gives the Dominion a foothold in the Alpha Quadrant. The Dominion War begins in "Call to Arms" when the crew mine the entrance to the wormhole to stop more Dominion vessels coming through. The Dominion invasion brings to an end two storylines, it concludes the Maquis storyline when they are wiped out by the Dominion and the Klingon renew the Khitomer Accords alliance with the Federation in the face of the Dominion threat.
To celebrate the thirtieth anniversary of Star Trek, the episode "Trials and Tribble-ations" sees Captain Sisko and the crew of the Defiant sent back in time to the setting of the original series, where they must save Captain Kirk's life.
Returning characters include Dukat, Garak, Nog, Rom, Eddington, Kasidy Yates, Leeta, Keiko, Molly, Zek, Kor, Gowron, Brunt, Shakaar, Damar, Weyoun, Martok, Ziyal, Ishka, Muniz, Ghemor, Grilka and Dr. Mora. Dr. Zimmerman and a EMH make guest appearances.
- "Apocalypse Rising"
- "The Ship"
- "Looking for par'Mach in All the Wrong Places"
- "Nor the Battle to the Strong"
- "The Assignment"
- "Trials and Tribble-ations"
- "Let He Who Is Without Sin..."
- "Things Past"
- "The Ascent"
- "The Darkness and the Light"
- "The Begotten"
- "For the Uniform"
- "In Purgatory's Shadow"
- "By Inferno's Light"
- "Doctor Bashir, I Presume"
- "A Simple Investigation"
- "Business as Usual"
- "Ties of Blood and Water"
- "Ferengi Love Songs"
- "Soldiers of the Empire"
- "Children of Time"
- "Blaze of Glory"
- "Empok Nor"
- "In the Cards"
- "Call to Arms"
Novels set during the fifth season
- DS9 novel: Legends of the Ferengi
- DS9 novel: Trials and Tribble-ations
- DS9 novel: Call to Arms...
- DS9 novel: Vengeance
- DS9 novel: The Conquered
- DS9 novel: The Courageous
- DS9 novel: The Liberated
- DS9 novel: The Mist
Comics set during the fifth season
- DS9 comic: "Lwaxana Troi and the Wedding of Doom"
- DS9 comic: "Four Funerals and a Wedding"
- DS9 comic: "Command Decisions"
- DS9 - Telepathy War comic: "Day of Honor"
- DS9 comic: "Nobody Knows the Tribbles I've Seen"
- DS9 comic: "Requiem in Obsidian"