Starbase 222 was a Federation starbase in service during the 24th century.
History
In 2367, three Borg cubes passed Starbase 222 traveling in excess of warp 9.9. (TNG novel: Vendetta)
In 2377, the USS da Vinci set course for Starbase 222 after shutting down Dancing Star and letting gravity drag it within the core of the star Cardienne. (CoE eBook: Collective Hindsight)