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Starbase 343 was a Federation starbase, located in the near Alpha Leonis and the Paulson Nebula.
Overview
Due to its location, the medical supply stations found itself dealing with the Ferengi more then the average station posts. Since Starfleet is very honest on the buying price, Ferengi would often travel to the station to trade their medical supplies, biological samples and anything of scientific value. The high level of traffic made it hard for the administrators to keep track of the inventory. (TLE novel: The Art of the Impossible; Decipher module: Starfleet Operations Manual)
History
In 2366 the USS Enterprise-D was diverted from their rendezvous with the USS Goddard to urgently deliver medical supplies to the station. (TNG episode: "The Vengeance Factor")
During the Borg Invasion of 2381, Starbase 343 was one of five simultaneous attacks along with bases 157 and 234 and the planets of Khitomer and Korvat. The USS Excalibur-A protected the base during the battle, they used phase inverter technique to augment torpedoes and destroyed the cube. (ST - Destiny novel: Gods of Night)