In the late 24th century, the 22nd Fleet was a standing fleet, centered around Starbase 173 and other key Federation outposts along the Romulan Neutral Zone. While the 22nd was assembled as a defense against the Romulan Star Empire, this fleet has found itself on the front lines of incoming Borg attacks as well. (Decipher RPG module: Starfleet Operations Manual)
In the year 2366, the 22nd was commanded by Vice Admiral J.P. Hanson, and he assembled a team to investigate options in case of Borg attack. Lieutenant Commander Elizabeth Shelby was in charge of this operation. Tactical response training in this fleet frequently consists of scenarios of captured starships, due to the high possibility a potential conflict will put them in contact with friendly or neutral vessels that have been boarded by Romulans or assimilated by Borg. (Last Unicorn RPG module: The Price of Freedom; Decipher RPG module: Starfleet Operations Manual)
- Vice Admiral J.P. Hanson (Fleet CO, until 2367)
- Lieutenant Commander Elizabeth Shelby (Borg tactics, until 2367)
The RPG The Dominion War Sourcebook: The Fires of Armageddon, published by Last Unicorn Games after they had lost their Star Trek licence, states that the 22nd and 30th Fleets reinforced the defense of Andoria following the fall of Betazed during the 2370s Dominion War. The 22nd and 15th Fleets also participated in the Battle of Ricktor Prime during that conflict.