In 2154, Arik Soong exposed a doctor at Cold Station 12 to Symbalene blood burn to force Jeremy Lucas to reveal the access codes to a vault holding Augment embryos from the Eugenics Wars. The disease eventually killed the doctor. (ENT episode: "Cold Station 12")
In 2282, Symbalene blood burn was diagnosed on the Federation observation outpost at Te Awamutu VII. The USS Reliant's medical staff cured it immediately with the help of Bianca Wilder, Pavel Chekov and Clark Terrell. (ST comic: "Alien Spotlight: The Gorn")
- This disease may have been intended to be the same as Cymbeline blood burn.