Upon the initial survey conducted on the region, the Federation, Klingon Empire and the Romulan Star Empire began immediate attempts to colonize the region and make use of its resources while, at the same time, stopping the attempts of the other powers from taking the valuable region of worlds.
Unaware to the three respective factions, most of these new worlds were inhabited by alien races which were initially left in stasis for milennia, but the transition back to normal space awakened them, giving the Federation, Klingons and Romulans more than what they bargained for. (TOS video game: New Worlds)
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