Theta Cygni XII was the twelfth planet in the Theta Cygni star system. Its native population became extinct near 2135 when neural parasites travelling from system to system infected the population. The neural parasites had arrived from Levinius V and reached Ingraham B after ravaging Theta Cygni XII. (ENT - Rise of the Federation novel: Live by the Code; TOS episode: "Operation -- Annihilate!")

In 2165 a Tellarite freighter reported receiving a distress call from Theta Cygni XII. In response Starfleet dispatched the USS Essex to investigate. Captain Bryce Shumar reported to Admiral Jonathan Archer that his ship found all life on the planet had been destroyed due to chemical and bacteriological warfare. Shumar further informed Archer that the few surviving clues indicated the planet suffered a wave of mass insanity, and that a number of ships were launched prior to the final war on that world. Because Theta Cygni burned hot the crew did not have a reliable means of tracking where the ships had gone due to the interference generated by the star. (ENT - Rise of the Federation novel: Live by the Code)

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