- For other uses, see Lexington.
In 2345, the Lexington held an important diplomatic conference between the Federation and the Antedeans. One of the Federation Ambassadors was Curzon Dax, who became friends with the Lexington's chief of security, Lieutenant Declan Keogh.
In 2348, the Lexington was called to planet Altair VI, when the planet was attacked by the an-Jirok. The Lexington was able to repel the attack, but because of Lt. Keogh's sluggish reactions due to a hangover, five officers died. (DS9 - The Brave and the Bold, Book One novella: The Second Artifact)
- The Decipher RPG module: Starfleet Operations Manual confuses this ship with the Nebula-class USS Lexington for the transporting of emergency medical supplies to Taranko colony in 2370.