The USS Panama was an Equus-class Starfleet cargo transport in service in the 23rd century. It was assigned to Starbase 47-Vanguard in the late 2260s and commanded by Captain Telvane.

In 2268, the Panama was part of the small fleet of starships that defended Vanguard from an attack by a Tholian armada. Along with the USS Sagittarius, the Panama covered zones one and two around the starbase. During the battle, the transport's starboard shields collapsed and the Sagittarius swung in to draw away enemy fire. Not long afterwards, the Panama broke apart before being destroyed in an explosion. (VAN novel: Storming Heaven)