Vanguard could refer to:
- Real-life topics:
- Star Trek: Vanguard, a TOS-era novel series
- Locations:
- Vanguard (station), the name of Starbase 47, the setting of the Vanguard series
- Vanguard (mirror station), the mirror version of the station
- Vanguard Colony, an Earth asteroid colony, later known as Holy Vangar to the Neyal
- Vanguard Complex, a Kam'Jahtae space station
- Vanguard (station), the name of Starbase 47, the setting of the Vanguard series
- Starships and vehicles:
- Vanguard-class (transport), a 22nd century ship class
- Vanguard-class (star cruiser), a 25th century ship class
- Vanguard-class (spine vessel), a type of Kam'Jahtae ship
- Vanguard-class (phaser tank), a type of Federation ground vehicle
- USS Vanguard (NCC-1536), a Miranda-class ship
- USS Vanguard (Sovereign-class)
- USS Vanguard (Venture-class)
- USS Vanguard (Section 31), a Section 31 ship that discovered Khan Noonien Singh in the alternate reality
- USS Vanguard (Arbiter-class)
- USS Vanguard (Constitution-class)
- USS Vanguard (Defender-class)
- USS Vanguard (Guardian-class)
- USS Vanguard (Interceptor-class)
- USS Vanguard (Intrepid-class)
- USS Vanguard (NCC-2360)
- USS Vanguard (proposed), a proposed Federation starship construction to be built sometime after the mid-to-late 24th century
- ISS Vanguard, a Terran Empire Vanguard-class starship
- Vanguard (starship), a Tyrion vessel
- Organizations:
- The Vanguard, a political organization in the Federation who advocated a more hostile stance to their enemies
- Objects and terms:
- vanguard (Klingon), Klingon guard position in the 23rd century
- vanguard (piece), playing piece in klin zha
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