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Between 2264 and 2270, the USS Enterprise (NCC-1701) was under the command of CaptainJames T. Kirk. During his tenure as captain, the Enterprise was a major component in many events of Alpha Quadrant history, as well as minor, run-of-the-mill missions. Below is a list of all adventures undertaken by the Enterprise during the final year of the historic five-year mission, from 2269-2270.
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After spending a week studying Beta Castelli, the Enterprise observed the star's death and the destruction of Zirgosian space. Shortly after, it was discovered that a spatial rift had been created by the Sackers and was leading to our universe merging with another. The process was reversed when the Enterprise used a baryon inverter on the rift. (TOSnovel: The Three-Minute Universe)
While performing a survey of Talin IV, the Enterprise's warp drive was prematurely activated while within the planet's gravity well, leading to widespread destruction on the surface. Over the next four months, the Enterprise's five-year mission was canceled, and the senior officers were either demoted or forced to resign. Investigations by the crew revealed that the disaster was caused by an alien hive-mind intelligence, and the Enterprise crew were exonerated of any wrong-doing. (TOSnovel: Prime Directive)
Stardate 4011.9
The Enterprise was conducted a star-mapping expedition near the Shapley Center on the opposite side of Klingon space, when war between the Federation and the Empire broke out once again. Captain Kirk decided to proceed to Organia to appeal to the Organians but the journey would take months. Spock volunteered to be sent to Organia in tachyonic form using the transporter, but the result was two duplicate Spocks. Eventually, the Enterprise reached Organia and after freeing them from a Klingon created "thought-barrier" the Organians confined the Klingons to their homeworld for 1000 years. (TOSnovel: Spock Must Die!)
Stardate 6720.8
After eight days in orbit of Kyros, the Enterprise's trilithium modulator crystals were sabotaged by Spock, effectively stranding the Enterprise in orbit. Spock had been possessed by a revolutionary from the planet due to the experimental cyphalic implant that he was wearing. Thankfully, the situation was resolved and the Enterprise repaired. (TOSnovel: Spock, Messiah!)
This story takes place shortly after Spock Must Die! because of McCoy's comment that the last time they used the transporter they had two Spocks.
Stardate 5268.1
When the Enterprise crew began to experience dreams about their former crewmate, Janice Rand, Captain Kirk began investigating, and discovered that Rand was missing in action following a covert mission to monitor the Chuniikites. The crew discovered her whereabouts after Spock supposed that the dreams were her sending clues to her location. Kirk found Rand in a derelict city on an uninhabited planet, and with Rand's help the two officers escape the Chuniikites and flee the planet. (TOScomic: "The Dream Walkers")
This story is placed here due to Rand's appearance in The Abode of Life.
Stardate 5064.4
Following a layover at Starbase 4, the Enterprise began an investigation of gravitic anomalies in the Sagittarius Arm of the galaxy. As a result the Enterprise was flung over 300 parsecs to the planet Mercan. The ship needed repairs to their engines, so Captain Kirk led landing party to contact the Mercans, where they discovered that the star Mercaniad was becoming very unstable, and with the signing of an agreement with the Mercans, the Enterprise stopped Mercaniad going nova, before returning home. (TOScomic: "The Abode of Life")
Stardate 7521.6
After transporting prisoners to the planet Trefolg, the Enterprise was diverted to the Trellisane along the Romulan Neutral Zone. The Enterprise was instrumental in creating a peace accord between the Federation, the Klingons, and the Romulans. (TOSnovel: The Trellisane Confrontation)
The Enterprise is ordered to Aritani to investigate pirate attacks on the native population. While investigating, Spock is confronted by three pirate fighters commanded by Romulans, and jumps off a precipice causing severe physical damage and amnesia. While Spock is recovering from his injuries on Vulcan, the Enterprise transports Federation Council members to an emergency meeting on the Aritani situation. With assistance from a Romulan double-agent, the Enterprise crew manages to destroy the Romulans secret base. (TOSnovel: Mindshadow)
Dr. McCoy states that it has been three-years since he last saw his daughter, Joanna.
The Enterprise transports a group of Hydrillan researchers from Beekman's Planet to Vulcan. Unbeknown to the crew of the Enterprise, they are also transporting a group of non-corporeal beings who wish to enslave Vulcan. (TOS novel: Demons )
After being having enhanced sensors installed, the Enterprise returns to investigate the gravitational anomalies they were studying on stardate 5064.4. Also accompanying the Enterprise is the new sensors' designer, Dr. Jason Crandall. Once again, the starship is transported thousands of light-years into an interstellar conflict between the Hoshan and the Zeator. After negotiating a peace between the two races, the Enterprise crew discover that the anomalies are gateways created by an unknown ancient race. (TOSnovel: Chain of Attack)
Given McCoy's statement in Mindshadow, this story must take place after.
A few weeks after the Enterprise's journey through the interstellar gateways, she discovers the USS Cochise. The Cochise has been invaded by an alien life-form from the gateway's. After once again traveling through the gateways, the Enterprise discovers the final nexus and the secrets to the system. (TOSnovel: The Final Nexus)
After being ordered to the Federation research outpost on the planet Tanis, the Enterprise crew discover that biological warfare experiments, sponsored by Admiral José Mendez, are being performed at the outpost. Following this, the Enterprise heads for Starbase 13 for shore leave. (TOSnovel: Bloodthirst)
During this story the date of October 31st is given. It has also been several months since Demons.
The Enterprise is ordered to the planet Chyrellkan system to mediate a dispute between the two planets of the system. After beaming down to negotiate, Spock and Dr. McCoy are taken prisoner by militants. The whole action is later revealed to be a plot by Benjamin Finney to get revenge on Captain Kirk. (TOSnovel: Renegade)
After being held prisoner for three months by the Klingons, Federation Agricultural Specialist, Jean Czerny, was released into the Enterprise's custody at Deep Space Station K-7. Czerny had been kidnapped by Commander Kang to solve the Klingon Empire's food crisis. (TOSnovel: Pawns and Symbols)
Stardate 5000.1
The Enterprise spends six weeks studying the decay of a singularity. In an alternate timeline, the Enterprise was diverted to Aleph Prime to transport Dr. Georges Mordreaux to a penal colony. During the mission, Captain Kirk was killed by Mordreaux. The timeline was reset when Spock traveled back in time to prevent the Enterprise being summoned. (TOSnovel: The Entropy Effect)
Stardate 6324.09
Following a star-mapping mission in Sector 70.2, the Enterprise docked at Starbase 11 for repairs and inspection detail. During that time, Spock journeyed to the planet Gateway and returned to Sarpeidon via the Guardian of Forever and brought his son Zar into the present. Shortly after, the Enterprise managed to prevent a Romulan invasion of the planet. (TOS - The Yesterday Saganovel: Yesterday's Son)
Stardate 3126.7
Following a layover at Starbase 24, the Enterprise was dispatched to the planet Taygeta V. On the planet they managed to stop the slaughter of the Singers and the subsequent spatial distortion. The Enterprise then proceeded to Starbase 23 for repairs. (TOSnovel: The Tears of the Singers)
Following an extensive refit at Starbase 23, the Enterprise was ordered to the oceanic planet, Okeanos, to settle a dispute between the Susuru and a human colony. The Enterprise managed to settle the power-struggle, but not without the interference of Commander Kain and the new Klingon dreadnought, IKS Leviathan. (TOSnovel: From the Depths)
This story takes place 207 years after Zefram Cochrane's warp flight (i.e 2063+207=2270).
After being declared physically fit for duty, the Enterprise was tasked with transporting Captain Garth of Izar back to Antos IV, following his crippling madness. Garth's mission was to repair the sociological damage he caused on the Antosians following his madness, and with Kirk's help, managed to maneuver Antosian rebels to exile themselves on to the island of Acra. (TOSnovel: Garth of Izar)
The Enterprise was summoned to a remote planet on the edge of Federation space, and discovered an unscrupulous scientist excavating on the surface of the planet. Soon after, the Gorn arrived and the Gorn captain, S'alath, who Kirk last faced during the Cestus III mission, demands to know why the Federation are excavating on a Gorn cemetery world. Kirk managed to restore the peace by surrendering to S'Alath. (TOScomic: "Dying of the Light")
Shortly after, the Enterprise was summoned to Starbase 6 for an urgent conference on Klingon Neutral Zone policy. However, the conference was interrupted when a Klingon squad attacked and took Kirk and several aides hostage. Realizing that the Klingons were not behaving as expected, Spock turned to Commander Kor for help, and they succeeded in freeing the hostages. (TOScomic: "Action of the Tiger")
Stardate 5989.6
After discovering a wormhole leading to a pocket universe, the Enterprise soon detected a form of communication coming from the other side. Captain Kirk led a shuttle expedition along with Lieutenants Sulu and Uhura. Captain Kirk was injured during the mission, leaving Uhura in command, who successfully established contact with the aliens, and returned to the Enterprise. (TOScomic: "Message in a Bottle")
Shortly after, the Enterprise was dispatched to the Romulan Neutral Zone to distract the Romulans while Commander Scott and a team from Starfleet Security infiltrated Romulan space to find the engineering hull of a Constitution-class vessel. However the team were unsuccessful in rescuing the experimental warp drive aboard the vessel, designed by Dr. Virgil Brahms. (TOScomic: "None But the Brave")
Shortly after, Captain Kirk leads a landing party aboard a shuttlecraft on a planetary survey. The Enterprise was forced to find them after the party was captured by the natives of the planet, who were genetically engineered. (TOScomic: "As Flies to Wanton Boys")
Stardate 5997.1
After beating a group of Klingons at a game of cards, Sulu and Chekov head back to the Enterprise in a new shuttlecraft. Unknown to the both crewmembers, Chekov now found himself as head of a Klingon house. The shuttle was attacked by various parties who want to rule the house for themselves, but Sulu's helm skills and Chekov's ingenuity allow them to safely return to the Enterprise. (TOScomic: "Trekkers")
Stardate 5998.6
The Enterprise crew are informed that their five-year mission is officially over. Before heading to Earth, they proceeded to Starbase 10 to take Commander Willard Decker aboard. En route to Earth, the ship is diverted to Talos IV by a Talosian illusion affecting the crew. On arrival, they discover that Commander Koloth and a Klingon task force had invaded Talos and had learned how to use the Talosians telepathic powers. Captain Kirk and the Talosians are able to defeat the Klingons, and leave them at the mercy of Talosian illusions of peace and tranquility. (TOScomic: "The Final Voyage")
Stardate 6205.7
While on a cadet training mission, the Enterprise became the victim of sabotage when a bomb was set off on the bridge, resulting in the deaths of several cadets. Believing an outside source to be responsible, Spock set up a fake court-martial and went undercover, where he was captured by the Tomariians who were responsible for the attack. Spock was rescued by the repaired Enterprise, but that ship was again heavily damaged following the battle with Tomariian and Romulan warships. As a result the Enterprise returned to Earth for heavy refitting. (TOSnovel: Black Fire)
Black Fire was meant to lead into the refit of Enterprise in time for Star Trek: The Motion Picture, however other sources describe different events leading up to this point.