- For another meaning of "Witch", please see Witch (shuttle).
During the late 17th century in the settlement of Salem on Earth, some Megans—who were living as humans—were accused of being witches and given the death penalty during the Salem witch trials. (TAS episode: "The Magicks of Megas-Tu")
On the planet Pyris VII in the year 2267, three illusory witches appeared before a landing party from the USS Enterprise as part of a study conducted by Korob and Sylvia. (TOS episode & Star Trek 8 novelization: Catspaw)
In the year 2273, a witch named Black Annis appeared aboard the USS Enterprise and terrorised Montgomery Scott. She also injured several of the Enterprise crew and killed two security guards. Black Annis was later revealed to be created by Andrea Manning from Commander Scott's subconscious. (TOS comic: "... Like a Woman Scorned!")